Injectable device delivers nano-view of the brain

first_imgIt’s a notion that might have come from the pages of a science-fiction novel — an electronic device that can be injected directly into the brain, or other body parts, and treat everything from neurodegenerative disorders to paralysis.Sounds unlikely, until you visit Charles Lieber’s lab.Led by Lieber, the Mark Hyman Jr. Professor of Chemistry, an international team of researchers has developed a method of fabricating nanoscale electronic scaffolds that can be injected via syringe. The scaffolds can then be connected to devices and used to monitor neural activity, stimulate tissues, or even promote regeneration of neurons. The research is described in a June 8 paper in Nature Nanotechnology.Contributors to the work include Jia Liu, Tian-Ming Fu, Zengguang Cheng, Guosong Hong, Tao Zhou, Lihua Jin, Madhavi Duvvuri, Zhe Jiang, Peter Kruskal, Chong Xie, Zhigang Suo, and Ying Fang.“I do feel that this has the potential to be revolutionary,” said Lieber, who holds a joint appointment in the Harvard Paulson School of Engineering and Applied Sciences. “This opens up a completely new frontier where we can explore the interface between electronic structures and biology. For the past 30 years, people have made incremental improvements in micro-fabrication techniques that have allowed us to make rigid probes smaller and smaller, but no one has addressed this issue — the electronics/cellular interface — at the level at which biology works.”In an earlier study, scientists in Lieber’s lab demonstrated that cardiac or nerve cells grown with embedded scaffolds could be used to create “cyborg” tissue. Researchers were then able to record electrical signals generated by the tissue, and to measure changes in those signals as they administered cardio- or neuro-stimulating drugs.“We were able to demonstrate that we could make this scaffold and culture cells within it, but we didn’t really have an idea how to insert that into pre-existing tissue,” Lieber said. “But if you want to study the brain or develop the tools to explore the brain-machine interface, you need to stick something into the body. When releasing the electronic scaffold completely from the fabrication substrate, we noticed that it was almost invisible and very flexible, like a polymer, and could literally be sucked into a glass needle or pipette. From there, we simply asked, ‘Would it be possible to deliver the mesh electronics by syringe needle injection?’”Though not the first attempt at implanting electronics into the brain — deep brain stimulation has been used to treat a variety of disorders for decades — the nanofabricated scaffolds operate on a completely different scale.“Existing techniques are crude relative to the way the brain is wired,” Lieber said. “Whether it’s a silicon probe or flexible polymers … they cause inflammation in the tissue that requires periodically changing the position or the stimulation.“But with our injectable electronics, it’s as if it’s not there at all. They are one million times more flexible than any state-of-the-art flexible electronics and have subcellular feature sizes. They’re what I call ‘neuro-philic’ — they actually like to interact with neurons.”The process for fabricating the scaffolds is similar to that used to etch microchips, and begins with a dissolvable layer deposited on a substrate. To create the scaffold, researchers lay out a mesh of nanowires sandwiched in layers of organic polymer. The first layer is then dissolved, leaving the flexible mesh, which can be drawn into a needle and administered like any other injection.The input-output of the mesh can then be connected to standard measurement electronics so that the integrated devices can be addressed and used to stimulate or record neural activity.“These type of things have never been done before, from both a fundamental neuroscience and medical perspective,” Lieber said. “It’s really exciting — there are a lot of potential applications.”Going forward, researchers hope to better understand how the body reacts to the injectable electronics over longer periods.Harvard’s Office of Technology Development has filed for a provisional patent on the technology and is actively seeking commercialization opportunities.“The idea of being able to precisely position and record from very specific areas, or even from specific neurons over an extended period of time — this could, I think, make a huge impact on neuroscience,” Lieber said.last_img read more

Panamá’s Safe Neighborhoods program fights gangs with enforcement and rehabilitation

first_img“We are attacking gang culture in two ways: first, by extending a helping hand to any youth that wants to join a rehabilitation and reintegration process,” Aguilera said. “We will support those youths with psychological tools, and provide vocational and basic training so that they can become rehabilitated and reenter society by obtaining decent employment. On the other hand, gang members who continue to be involved in illegal activities will be held responsible for all the crimes they commit, to the fullest extent of the law.” “When they join the program, the members are required to undergo psychosocial evaluation before beginning basic and vocational education, which will allow them subsequently to have a chance to gain employment,” Aguilera said. “The youths [in the program] must make a commitment to abandon their weapons and their life of crime. The government, in turn, has contacts within private companies and in the public sector who have proven willing to hire [former gang members] and to give them a chance in society.” “With the establishment of this task force, the President is sending a clear message to these gang members to abandon their activities,” Aguilera added. The response has been strong. As of mid-November, 2,000 former gang members have joined the program, according the Minister for Public Security Rodolfo Aguilera. Some of the former gang members who joined the initiative turned in 200 weapons. The Ministry of Public Security (Minseg) formed five commissions, comprised of public servants, civilians, evangelical pastors, and members of NGOs, to collect the weapons. “We are attacking gang culture in two ways: first, by extending a helping hand to any youth that wants to join a rehabilitation and reintegration process,” Aguilera said. “We will support those youths with psychological tools, and provide vocational and basic training so that they can become rehabilitated and reenter society by obtaining decent employment. On the other hand, gang members who continue to be involved in illegal activities will be held responsible for all the crimes they commit, to the fullest extent of the law.” Job training, sports, and cultural activities “When they join the program, the members are required to undergo psychosocial evaluation before beginning basic and vocational education, which will allow them subsequently to have a chance to gain employment,” Aguilera said. “The youths [in the program] must make a commitment to abandon their weapons and their life of crime. The government, in turn, has contacts within private companies and in the public sector who have proven willing to hire [former gang members] and to give them a chance in society.” Panamá President Juan Carlos Varela’s administration is taking aim at gangs with a two-pronged strategy that includes strong law enforcement efforts with rehabilitation initiatives and social integration opportunities for those who wish to reject a life of crime. Congratulations to our heroes. The police struggle against the gangs is important, but even more important is to overcome the social inequalities produced by these gangs.. The effort being made in several countries is praiseworthy. I hope something like this is done in Honduras. The Panamanian model is effective, Job training, sports, and cultural activities Safe Neighborhoods is aimed at the 192 gangs which have a total of 5,000 members operating in Panamá. These gang members are between the ages of 8 and 29 years old, according to the National Integrated Criminal Statistics System (SIEC). They engage in homicide, drug trafficking, kidnapping, theft, and extortion, and many of these gangs fight each other for control of specific neighborhoods throughout the country. One of the groups working to help former gangsters rehabilitate themselves and find honest employment is the Jesús Luz de Oportunidades Foundation. For six years, the organization has provided rehabilitation and re-socialization services for gang members in Santa Ana, El Chorrillo, Curundú, San Felipe, and Avenida Ancón. To encourage gang members to leave behind these criminal activities, the Safe Neighborhoods program is providing social assistance to at-risk young people, such as $50 in food coupons per week, job training; and sports, cultural, and spiritual activities. The program is concentrated in regions with the highest levels of gang activity, such as the provinces of Colón, Chiriquí, Panamá Oeste (Arraiján and La Chorrera); and the districts of San Miguelito, Panamá Este and Centro. center_img Safe Neighborhoods is aimed at the 192 gangs which have a total of 5,000 members operating in Panamá. These gang members are between the ages of 8 and 29 years old, according to the National Integrated Criminal Statistics System (SIEC). They engage in homicide, drug trafficking, kidnapping, theft, and extortion, and many of these gangs fight each other for control of specific neighborhoods throughout the country. One of the groups working to help former gangsters rehabilitate themselves and find honest employment is the Jesús Luz de Oportunidades Foundation. For six years, the organization has provided rehabilitation and re-socialization services for gang members in Santa Ana, El Chorrillo, Curundú, San Felipe, and Avenida Ancón. Regarding enforcement, the initiative brings together 15,000 members of the security forces, who collectively form the Anti-Gang Task Force. The task force coordinates the efforts of units of the National Police, the National Border Protection Service, the National Aeronautical Service, and the anti-gang division of the Directorate of Judicial Investigation of the National Police. Regarding enforcement, the initiative brings together 15,000 members of the security forces, who collectively form the Anti-Gang Task Force. The task force coordinates the efforts of units of the National Police, the National Border Protection Service, the National Aeronautical Service, and the anti-gang division of the Directorate of Judicial Investigation of the National Police. To encourage gang members to leave behind these criminal activities, the Safe Neighborhoods program is providing social assistance to at-risk young people, such as $50 in food coupons per week, job training; and sports, cultural, and spiritual activities. The program is concentrated in regions with the highest levels of gang activity, such as the provinces of Colón, Chiriquí, Panamá Oeste (Arraiján and La Chorrera); and the districts of San Miguelito, Panamá Este and Centro. The “Safe Neighborhoods with more Opportunities and a Firm Hand” program was launched on July 1, when Varela was sworn into office. The new president publicly announced a month-long amnesty period for gang members to voluntarily surrender their weapons. He encouraged gang members who wanted to change their lives to join the program. Safe Neighborhoods is also open to delinquents who are not affiliated with a gang. The “Safe Neighborhoods with more Opportunities and a Firm Hand” program was launched on July 1, when Varela was sworn into office. The new president publicly announced a month-long amnesty period for gang members to voluntarily surrender their weapons. He encouraged gang members who wanted to change their lives to join the program. Safe Neighborhoods is also open to delinquents who are not affiliated with a gang. Panamá President Juan Carlos Varela’s administration is taking aim at gangs with a two-pronged strategy that includes strong law enforcement efforts with rehabilitation initiatives and social integration opportunities for those who wish to reject a life of crime. By Dialogo November 25, 2014 “With the establishment of this task force, the President is sending a clear message to these gang members to abandon their activities,” Aguilera added. The response has been strong. As of mid-November, 2,000 former gang members have joined the program, according the Minister for Public Security Rodolfo Aguilera. Some of the former gang members who joined the initiative turned in 200 weapons. The Ministry of Public Security (Minseg) formed five commissions, comprised of public servants, civilians, evangelical pastors, and members of NGOs, to collect the weapons. last_img read more

Join the race to excellence: Register for THINK 18

first_img 7SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr “In a world where everything is moving so rapidly, simply being fast isn’t enough; you have to be faster than anyone and everyone. Accelerate until you’re at the front and move fast to stay there.” – Jeff Lerner, owner and CEO of XurliHow fast does the digital world spin? Consumer expectations, technological breakthroughs and a culture of change demand a constant whirlwind of innovation and action. Yet, it’s never been more critical to develop a deep understanding of where the world, your members and your organization are heading.It’s a race to excellence.Join us at THINK 18, the premier credit union innovation conference, May 7 to 10, 2018, at the Sheraton Grand at Wild Horse Pass in Chandler, Arizona. This year’s theme, “The Race to Excellence,” will fuel an action-packed four days of all-star keynotes, lively dialogue and debate, and collaborative strategizing in an unparalleled setting of natural beauty. continue reading »last_img read more

Trump is ignorant of Constitution

first_imgWhile at a rally in Moon Township, Penn., on March 10, the so-called president of our republic and leader of the free world once again displayed his ignorance. The human garbage Republicans want us to respect mentioned executing drug dealers. Once again, the cretin showed just how ignorant he is. I certainly think this would be cruel and unusual punishment, forbidden in the Constitution. His pal, Rodrigo Duterte, a despot who is praised by 45, has drug dealers, young and old, executed without due process on the streets of Manila, Philippines.I’d unequivocally say this murderer is a role model for the white supremacists, including 45.Paul SantoRotterdamMore from The Daily Gazette:EDITORIAL: Urgent: Today is the last day to complete the censusEDITORIAL: Beware of voter intimidationEDITORIAL: Find a way to get family members into nursing homesFoss: Should main downtown branch of the Schenectady County Public Library reopen?Car hits garage in Rotterdam Sunday morning; Garage, car burn Categories: Letters to the Editor, Opinionlast_img read more

Asia battles second wave of coronavirus with fresh lockdowns

first_imgCountries around Asia are confronting a second wave of coronavirus infections and are clamping down again to try to contain the disease, with Australia recording a record daily rise in cases and Vietnam locking down the city of Danang.In China, infections not involving people returning from overseas hit the highest number since early March, with a total of 57 domestic transmissions reported out of 61 new cases.In the northeast, Liaoning province reported a fifth straight day of new infections and Jilin province reported two new cases, its first since late May. Hong Kong is expected to announce further restrictions on Monday including a ban on restaurant dining and mandated face masks outdoors, local media reported.The measures, which are expected to take effect from Wednesday, would be the first time the city has completely banned dining in restaurants. Since late January, more than 2,600 people have been infected in Hong Kong, 19 of whom have died.Australian authorities warned a six-week lockdown in parts of southeastern Victoria state may last longer after the country registered its highest daily increase in infections.Most of Australia is effectively virus-free but flare-ups in the two most populous southeastern states have authorities scrambling to prevent a wider national outbreak. Victoria reported a daily record of 532 new cases on Monday and six more deaths, taking the state toll to 77, almost half the total national death toll.In Japan, the government said it would urge businesses to increase telecommuting and enhance other social distancing measures amid a rise in coronavirus cases among workers.Japan has avoided mass infections but a record surge in cases during the past week in Tokyo and other urban centers has experts worried the country faces a second wave.Tokyo last week reported a daily record of 366 cases, with 239 on Sunday. The southern city of Fukuoka reported a record 90 cases on Sunday, along with rising numbers in Osaka.Vietnam is evacuating 80,000 people, mostly local tourists, from the central city of Danang after three residents tested positive for the coronavirus at the weekend, the government said on Monday.The Southeast Asian country is back on high alert after the government on Saturday confirmed its first community infections since April, and another three cases on Sunday, all in Danang.Philippine President Rodrigo Duterte is expected to focus on COVID-19 and the economy in his annual State of the Nation Address later on Monday, amid a renewed coronavirus outbreak.Manila is weighing whether to re-impose stricter lockdown measures after easing them saw a dramatic surge in infections, with 62,326 cases reported since June 1.North Korean state media reported on the weekend that the border town of Kaesong was in lockdown after a person who defected to South Korea three years ago returned this month with symptoms of COVID-19.If confirmed, it would be the first case officially acknowledged by North Korean authorities.North Korean leader Kim Jong Un convened an emergency politburo meeting in response to what he called a “critical situation in which the vicious virus could be said to have entered the country”, the KCNA state news reported.South Korea has reported more than 14,000 cases and 298 deaths from the pandemic. Saturday’s 113 infections were the highest on a single day since March 31.Indonesia is expected to report its 100,000th case on Monday, having surpassed China with the highest number of cases and deaths in East Asia.More than 16.13 million people have been reported to be infected by the novel coronavirus globally and 644,836​ have died, according to a Reuters tally.Topics :last_img read more

What Robin van Persie asked Sir Alex Ferguson ‘seconds’ before signing for Man Utd

first_imgAdvertisement Sir Alex Ferguson told Robin van Persie he would continue in management for another three years (Picture: Getty)Former Manchester United star Robin van Persie has revealed he asked Sir Alex Ferguson about his retirement plans just seconds before putting pen to paper on a deal to sign for the club.The Dutchman signed a four-year deal with the Red Devils in 2012 after United agreed a controversial £22million deal with rivals Arsenal.Van Persie had multiple offers to leave the Gunners and it appeared as though the race for his signature was a straight shootout between Juventus and Manchester City.However, the Dutchman chose Old Trafford after United entered the bidding late into the summer and he says Ferguson was the deciding factor in his decision.ADVERTISEMENT Comment Van Persie spent three years at Old Trafford (Picture: DAZN)‘We did struggle because we ended up being 7th,’ admitted Van Persie.‘From such a high…we were thinking about winning the Champions League and moving on.‘It was a new period as well with Scholesey coming to the end, Giggsy taking a player/coach role. It was all new. ‘Moyes was not to blame, anyone who came in after Ferguson good luck to you. It was not only him to blame, it was us as well. The standards were so high but they dropped.’MORE: Ian Wright reveals Arsene Wenger’s plan for ‘unbelievable’ Nicolas Anelka to partner Thierry Henry fell through Sean KearnsWednesday 13 May 2020 9:07 pmShare this article via facebookShare this article via twitterShare this article via messengerShare this with Share this article via emailShare this article via flipboardCopy link9.7kSharescenter_img What Robin van Persie asked Sir Alex Ferguson ‘seconds’ before signing for Man Utd Van Persie was desperate to add more silverware to his collection but he couldn’t manage it (Picture: Getty)But, though Van Persie was keen on a move to the Theatre of Dreams, he’s revealed that moments before he signed for the club he had to check with Ferguson how long he planned on continuing in management.AdvertisementAdvertisementFerguson told Van Pesie he intended on sticking round for at least another three years but he lasted just 12 months as he retired at the end of the season.Van Persie admits that came as a shock but he understood the decision.‘That was a bit of a shock,’ Van Persie told Premier League Productions. ‘Just before I signed, I literally had the pen in my hand and I said ‘One more thing Sir Alex, how much longer are you planning to stay?’ and he said ‘At least three more years’. ‘To be fair the reason why he stopped was family reasons and family comes first. ‘He was one of the big reasons I signed so it was a blow but then that is football. players come and go, managers too. He played 26 years and built the club up but that’s life.’More: FootballRio Ferdinand urges Ole Gunnar Solskjaer to drop Manchester United starChelsea defender Fikayo Tomori reveals why he made U-turn over transfer deadline day moveMikel Arteta rates Thomas Partey’s chances of making his Arsenal debut vs Man CityVan Persie still had three years to run on his four-year deal at the club when Ferguson retired and he was intent on adding to the league title that he won in his first campaign.However, United struggled in Ferguson’s absence, with his replacement David Moyes failing to see out his first season. Van Persie stuck around for a further 12 months under Louis van Gaal before departing and the Dutchman admits a drop in ‘standards’ was inevitable after Ferguson’s departure. Advertisementlast_img read more

Prior Group and ALL NRG Ink Offshore Wind Deal

first_imgPrior Group and ALL NRG have signed a Letter of Intent (LOI) to jointly cooperate on offshore wind projects.Under the deal that began in March, ALL NRG uses Prior Group’s facilities, such as offices, workshops, storage and service, as well as services from Prior’s in-house engineering, electrical company and yard in the Port of Vlissingen.The two parties said they will join forces when beneficial to customers and when it improves project results as they are together able to provide solutions which cannot be given as separate organizations.According to Prior, the collaboration will strengthen the presence of ALL NRG in Vlissingen and other ports in The Netherlands and Belgium.“To further expand our current business activities in the Benelux, teaming up with Prior Group is a strong benefit for ALL NRG,” said Hans Schneider, Chief Executive Officer of ALL NRG.“The joined competences of Prior Group and ALL NRG will be in high demand when the next major expansion of Dutch and Belgian offshore wind really starts to kick off. The well-established multidisciplinary organization in Prior Group with a vast local network adds excellent value to our core business – provision of manning and project solutions.”The companies are currently investigating opportunities that will take place in the Benelux area, including project activities at the new Green Blue Offshore Terminal in Vlissingen, which recently announced the opening of a new terminal to offer services to offshore wind companies.The new terminal contains 22.000m2 of workspace and will offer services during the construction, modification, repair and maintenance activities, and will serve as a place for the storage of equipment, materials, and offshore modules.last_img read more

French MPs back (symbolic) ban on smacking children

first_imgFrance24.com 30 November 2018Family First Comment: Interesting approach – but still flawed“France’s bill would not sanction parents who continue to “discipline” their children as its main goal is “educational” – a way to encourage society to mend its views. But it will slap down a 19th-century addendum to the Civil Code’s definition of parental authority, which is read out to couples during their wedding vows and that specifically allows for “disciplining” children.”The French National Assembly voted Friday in favour of a largely symbolic ban on parents smacking their children, a practice which though condemned by the UN still enjoys widespread support in the country.The bill on “corporal punishment or humiliation” seeks to ensure that parental authority is exercised “without violence” of any sort, including “physical, verbal or psychological” violence.MPs voted it through 51-1 early Friday morning, after a late-night debate, and it will now pass to the Senate.The draft law was proposed by an MP from the centrist Democratic Movement party, Maud Petit, but received the backing of French President Emmanuel Macron’s party, La République en Marche, and was boosted by the health minister Agnès Buzyn and the Secretary of Equality, Marlène Schiappa.Previous governments have attempted to ban the practice, but have been thwarted by conservatives. Eric Ciotti, an MP from conservative party The Republicans, said it was “propaganda legislation” pushing “pseudo official morality”.According to the non-governmental Childhood Foundation, 85 percent of French parents resort to corporal punishment. Schools have long been banned from physically punishing children, but not parents.READ MORE: https://www.france24.com/en/20181130-france-mps-national-assembly-back-ban-smacking-childrenlast_img read more

Agent wants Barca to move for Lautaro

first_img Loading… Agent Lorenzo De Santis expects Barcelona to move for Inter Milan striker Lautaro Martinez. “He has great room for improvement, he’s having a season of the highest level, the numbers show it. Given his age and performance the €111 million clause is attracting the attention of clubs like Barça. Read Also:Video:Braithwaite mocks shameful moment during Barca unveiling “Then it’s no mystery that Messi has a special feeling with him and hasn’t made it a mystery that he enjoys playing with him. It’s a negotiation that we will certainly find ourselves in the next market window.” FacebookTwitterWhatsAppEmail分享 center_img De Santis acknowledges Lautaro’s buyout clause makes him attractive to the Catalans. He told PassioneInter.com: “Lautaro is an extraordinary striker, still very young.Advertisementlast_img read more

Authorities Release Identity Of Twin Toddlers *Update*

first_imgUpdate (11:40 a.m. on April 9, 2014)Officials have released the identity of twin 2-year-old girls that died after being found in a neighbor’s pool Tuesday night.Dearborn County Deputies and Aurora Fire and EMS responded to the 5400 block of Dutch Hollow Rd. in reference to the two missing girls at 6:49 p.m.The toddlers were located two doors down in a neighbor’s pool on Elm Circle.Emergency personnel immediately began CPR and the children were transported to the Dearborn County Emergency Room, where they were later pronounced dead.The 2-year-old twins have been identified as Shaylyn and Jocelyn Spurlock, both of Aurora.Update (8:30 a.m. on April 9, 2014)Twin 2-year-old girls died after being found in a neighbor’s pool in Aurora. Dearborn County authorities received a report of the missing toddlers Tuesday night.The girls were found in the pool on Dutch Hollow Road around 8:15 p.m. and were transported to the Dearborn County Hospital, where they were pronounced dead.The case is under investigation by the Dearborn County Sheriff’s Office and more information will likely follow.Officials have not released the identity of the victims or the circumstances surrounding the deaths.First Report (11:30 p.m. on April 8, 2014)Dearborn County dispatchers said late Tuesday night that twin 2-year-old girls from Aurora have been transported to the hospital after being found in a pool.Officers responded to the location on Dutch Hollow Road.The case is being investigated by the Dearborn County Sheriff’s Office and more information may follow.Stay tuned to Country 103.9 WRBI and wrbiradio.com for continuing coverage in this developing story.last_img read more